Prof. Dr. med. Beate Winner

Prof. Dr. med. Beate Winner
Professor for stem cell models of rare neural diseases
IZKF Juniorgruppe III/ Humangenetisches Institut
Universitätsklinikum Erlangen
Friedrich-Alexander-Universität Erlangen-Nürnberg
Glückstr. 6
91054 Erlangen
Tel: +49 9131 8539301
Fax: +49-9131 8539311




Curriculum vitae

Beate Winner studied human medicine at the universities of Regensburg, Würzburg, and Toronto. She received her doctorate degree in 1999 at the University of Würzburg. From 1999 to 2007 she completed her specialist training and habilitation at the Clinic and Polyclinic for Neurology at the University of Regensburg. From 2007 to 2010 she held a Humboldt scholarship and worked in the laboratory of Prof. F.H. Gage at the Salk Institute, La Jolla, CA, USA. Since 2010, she has been an IZKF junior research group leader and head of a BMBF research group on neurosciences. In addition, she heads an associate junior research group within the framework of the Bavarian Research Network for Molecular Biosystems BioSysNet. Since 2016, she has been a professor for stem cell models of rare neural diseases at the Institute of Human Genetics in Erlangen (??). The focus of her work is the modeling of rare disorders of the nervous system using human stem cell models. The generation of stem cell models and neural derivatives for the analysis of disease phenotypes is her most important area of interest.

Important publications

Mishra HK, Prots I, Havlicek S, Kohl Z, Perez-Branguli F, Boerstler T, Anneser L, Minakaki G, Wend H, Hampl M, Leone M, Brückner M, Klucken J, Reis A, Boyer L, Schuierer G, Behrens J, Lampert A, Engel FB, Gage FH, Winkler J, Winner B. Rescue of GSK3/ß-Catenin-dependent human neuronal precursor proliferation defects in spatacsin-linked motor neuron disease. Annals of Neurology, Mar 11. doi: 10.1002/ana.24633. [Epub ahead of print]

Eberhardt E*, Havlicek S*, Schmidt D*, Link AS, Neacsu C, Kohl Z, Hampl M, Kist AM, Klinger A, Nau C, Schüttler J, Alzheimer C, Winkler J, Namer B, Winner B#, Lampert A#. Pattern of functional TTX-resistant sodium channels reveals developmental stage of human iPS- and ES cell-derived nociceptors. Stem Cell Reports, 2015 5(3):305-13. *# contributed equally

Winner B, Marchetto MC, Winkler J, Gage FH. Human-induced pluripotent stem cells pave the road for a better understanding of motor neuron disease. HMG, 2014; 23(R1):R27-34.

Havlicek S, Kohl Z, Mishra HK, Prots I, Eberhardt E, Denguir N, Wend H, Plötz S, Boyer S,Marchetto MCN, Aigner S, Sticht H, Groemer TW, Hehr U, Lampert A, Schlötzer-Schrehardt U, Winkler J, Gage FH, Winner B. (2014). Gene dosage dependent rescue of HSP neurite defects in SPG4 patients’ neurons. HMG 23:2527-41.

Winner B*, Jappelli R*, Maji SK*, Desplats P, Boyer L, Aigner S, Hetzer C, Loher T, Vilar M, Campioni S, Tzitzilonis C, Soragni A, Jessberger S, Mira H, Consiglio A, Pham E, Masliah E, Gage FH and Riek R. (2011). In vivo demonstration that a-synuclein oligomers are toxic. PNAS 108:4194-9. *contributed equally